HRMEM is committed to accelerating structural biology research across BC and Western Canada using high resolution cryo-transmission electron microscopy. From vaccine innovation to targeting novel avenues for drug design and LNP delivery, HRMEM has supported the research goals of academic research labs across institutions and dozens of industry partners.
As a member of the Canadian Cryo-EM Nexus, our open access facility proudly provides leading-edge instrumentation, training and consultation for both single particle and cryo electron tomography workflows. Equipped with a Glacios screening microscope, an energy filter enabled Titan Krios and the only Aquilos 2 Cryo-FIBMilling SEM in Canada, HRMEM’s cutting-edge technology is helping drive understanding and innovation both in vitro and in situ.
Interested?
Users Supported
- UBC Academic
- External Academic
- Industry
Techniques Available
- Single Particle Cryo-EM
- Cryo-Electron Tomography
- Negative Stain TEM
- Lipid Nanoparticle Characterization
- FIB milling/ Lamella Preparation
Featured Data
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Structure of Rab3GAP, guanine nucleotide exchange factor for Rab18 GTPase, obtained by Fairlie, Nguyen et al. (2025)
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Magnetic lipid nanoparticles were applied in exciting new technique by Francia, Zhang et al. (2024)
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Bacterial permease, AmpG, structure discovered by Sverak et al. (2024)
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Novel analysis tool (MCS-DETECT) by Cardoen, Vandevoorde, Gao, Ortiz-Silva et al. yields stunning insights into cell membrane behaviour (2023)
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Ryanodine receptor isoform 3, RyR3, structure determined by Chen et al. (2024)
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Liao et al. developed a technique to determine the pH inside LNPs using a pH-sensitive fluorescent dye-based DNA probe (2024)
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Structure of human ABCA4, a crucial transporter for ocular function in complex with AMP-PNP, was determined by Scortecci, Garces et al. (2021)
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Cryo-ET of Thermotoga maritima by Sexton et al. brought new insight to the evolution of bacterial membranes (2023)
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Alexander, Worrall et al. solved the challenging structure of BlaR1, a major mechanism for bacterial resistance (2023)
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Visualization of Weisser at al. anti-HER2 antibody which induces unique HER2 clustering (2023)
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Willegems, Eldstrom, Kyriakis, Ataei et al. uncover novel drug binding site on cardiac potassium channel, KCNQ1 (2022)
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Formation of DNA-PK synaptic complex captured by Hepburn et al. (2021)
It is critical to the ongoing funding of our facility that acknowledgement of the contributions of HRMEM are provided in your publications, posters and talks. Templates for the required acknowledgement statement and samples for the various methods sections are available through the link below.
We thank you for your collaboration!
Vancouver’s Favourite Cryo-EM Hub