Sverak et al, Cryo-EM characterization of the anydromuropeptide permease AmpG central to bacterial fitness and β-lactam antibiotic resistance, Nature Communications, 2024
Chen et al, Cryo-EM investigation of ryanodine receptor type 3, Nature Communications, 2024
Shaw et al, Structure of calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A, Structure, 2024
Zhao et al, Determination of the interior pH of lipid nanoparticles using a pH-sensitive fluorescent dye-based DNA probe, Biosensors and Bioelectronics, 2024
Francia et al, A magnetic separation method for isolating and characterizing the biomolecular corona of lipid nanoparticles, PNAS, 2024
Suresh et al, Molecular basis for plasma membrane recruitment of PI4KA by EFR3, bioRxiv [preprint], 2024
Li et al, Cryo-EM analysis of S. aureus TarL, a polymerase in wall teichoic acid biogenesis central to virulence and antibiotic resistance, Science Advances, 2024
Cardoen et al, Membrane contact site detection (MCS-DETECT) reveals dual control of rough mitochondria–ER contacts, Journal of Cell Biology, 2024.
Haji-Ghassemi et al, Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation, Science Advances, 2023
Harris et al, Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain, eLife, 2023
Cholak et al, Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives, Structure, 2023
Chander et al, Lipid nanoparticle mRNA systems containing high levels of sphingomyelin engender higher protein expression in hepatic and extra-hepatic tissues, Molecular Therapy Methods & Clinical Development, 2023
Meulewaeter et al, Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures, Journal of Controlled Release, 2023
Cheng et al, Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency, Advanced Materials, 2023
Sexton et al, The cell envelope of Thermatogae suggests a mechanism for outer membrane biogenesis, PNAS, 2023
Weisser et al, An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity, Nature Communications, 2023
Mo et al, Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles, ACS Nano, 2023
Alexander et al, Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus, Nature, 2023
An et al, On the Influence of Nucleic Acid Backbone Modifications on Lipid Nanoparticle Morphology, Langmuir, 2022
Dalwadi et al, Biochemical Characterization of the TINTIN Module of the NuA4 Complex Reveals Allosteric Regulation of Nucleosome Interaction, Molecular and Cellular Biology, 2022
Fayez et al, Development of a child-friendly oral drug formulation using liposomal multilamellar vesicle technology, International Journal of Pharmaceutics, 2022
Fayez et al, Hepatocyte-targeted delivery of imiquimod reduces hepatitis B virus surface antigen, Journal of Controlled Release, 2022
Gibbs et al, Rational Generation of Monoclonal Antibodies Selective for Pathogenic Forms of Alpha-Synuclein, Biomedicines, 2022
Vasyliuk et al, Conformational landscape of the yeast SAGA complex as revealed by cryo-EM, Scientific Reports, 2022
Willegems et al, Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277, Nature Communications, 2022
Dalwadi et al, Biochemical and Structural Characterization of Human Core Elongator and Its Subassemblies, ACS Omega, 2022
Sexton et al, Super-resolution confocal cryo-CLEM with cryo-FIB milling for in situ imaging of Deinococcus radiodurans, Current research in Structural Biology, 2022
Sexton et al, Ultrastructure of organohalide-respiring Dehalococcoidia revealed by cryo-electron tomography, Applied and Environmental Microbiology, 2022
Scortecci et al, Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease, Nature Communications, 2021
Rathinaswamy et al, Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation, Science Advances, 2021
Harris et al, Biochemical Insight into Novel Rab-GEF Activity of the Mammalian TRAPPIII Complex, JMB, 2021
Woll et al, Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM, Nature Communications, 2021
Henrickson et al, Density Matching Multi-wavelength Analytical Ultracentrifugation to Measure Drug Loading of Lipid Nanoparticle Formulations, ACS Nano, 2021
Lyons et al, Cryo-EM structure of the EspA filament from enteropathogenic Escherichia coli: revealing the mechanism of effector translocation in the T3SS, Structure, 2021
Hepburn et al, The active DNA-PK holoenzyme occupies a tensed state in a staggered synaptic complex, Structure, 2021
Sexton and Tocheva, Ultrastructure of Exospore Formation in Streptomyces Revealed by Cryo-Electron Tomography, Front. Microbiol., 2020
Ma et al, Structural basis for diamide modulation of ryanodine receptor, Nature Chemical Biology, 2020
Majewski et al, Cryo-EM analysis of the SctV cytosolic domain from the Enteropathogenic E.coli T3SS injectisome, J. Structural Biology, 2020
Hu et al, Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin, Nature Communications 9, 2018
Kulkarni et al, Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA, ACS Nano, 2018